That being said, the PREDPP library of specific subroutines provides the pharmacometrician with access to multiple prewritten subroutines for many common and typical PK models, all of which can be customized to meet the individual needs of a particular compound to facilitate model development. As such, NONMEM is by no means limited in its application to population and individual pharmacokinetic (PK) and pharmacokinetic/pharmacodynamic (PK/PD) applications. NONMEM, the heart of the program, consists of FORTRAN subroutines that govern the estimation of parameters of nonlinear mixed effects models. The NONMEM system consists of three major program components: NM-TRAN, the NonMem TRANslator PREDPP, subroutines for the PREDiction of Population Pharmacokinetic models and parameters and NONMEM, the engine for the estimation of NONlinear Mixed Effect Models. This chapter will describe many of the common control stream records, explain the various options that may be used with each, and provide examples of typical control stream statements. Therefore, a solid understanding of how to code simple control streams is required before building up to more and more advanced and complicated examples. Since NONMEM is run in batch mode (i.e., programs or control streams are written and submitted for execution all at once and not line-by-line), the coding of the NM-TRAN control stream is the fundamental building block upon which the rest of the system is built. NONMEM Overview and Writing an NM-TRAN Control StreamĪfter describing the main components of the NONMEM system, this chapter will provide a detailed explanation of the essential elements of coding an NM-TRAN control stream.
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